Medchemexpress LLC Ponatinib hydrochloride | 1114544-31-8 | 99.8% | 569.02 | 50 MG

Supplier:  Medchemexpress LLC HY10876610MG

Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. It is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src. This product offers several key features and benefits for research applications.

• Orally active multi-targeted kinase inhibitor
• IC50s: 0.24 nM for LYN, 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src
• Can reduce the viability, migration, and function of human endothelial cells in vitro
• Protects mice from lethal influenza infection by inhibiting cytokine storm in vivo
• Solid, off-white to light yellow appearance
• For research use only

Catalog No. 50-003-46182