Medchemexpress LLC Ponatinib hydrochloride (AP24534 hydrochloride) | 1114544-31-8 | 99.76% | 569.02 | 500 MG

Supplier:  Medchemexpress LLC HY108766100MG

Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride salt of ponatinib. It is an orally active multi-targeted kinase inhibitor with IC50 values of 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src.

• Orally active multi-targeted kinase inhibitor.
• Inhibits Abl with an IC50 of 0.37 nM.
• Targets PDGFRα with an IC50 of 1.1 nM.
• Inhibits VEGFR2 with an IC50 of 1.5 nM.
• Targets FGFR1 with an IC50 of 2.2 nM.
• Inhibits Src with an IC50 of 5.4 nM.
• Reduced viability, migration, and function of human endothelial cells in vitro.
• Protects mice from lethal influenza infection by inhibiting cytokine storm in vivo.

Catalog No. 50-003-45096