Medchemexpress LLC Ponatinib hydrochloride (AP24534 hydrochloride) | 1114544-31-8 | 99.8% | 569.02 | 100 U

Supplier:  Medchemexpress LLC HY10876650MG

Ponatinib hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively. It is for research use only and not sold to patients.

• Orally active multi-targeted kinase inhibitor
• IC50s: 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src
• Reduces viability, migration, and function of human endothelial cells in vitro
• Protects mice from lethal influenza infection by inhibiting cytokine storm in vivo

Catalog No. 50-003-45437