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Gibco™ Porcine GM-CSF, AOF Recombinant Protein

Catalog No. PIRP87802
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PIRP87802 500 μg
PIRP87798 100 μg
PIRP87800 1 mg
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Description

Recombinant Protein

Animal Origin Free Reconstitute with sterile water at 0.1 mg/mL.

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q29118
Concentration 0.1 mg/mL
For Use With (Application) Control
Formulation 10 mM sodium phosphate with no preservative
Gene ID (Entrez) 397208
Molecular Weight (g/mol) 14.5 kDa
Name Porcine GM-CSF, AOF
Quantity 500 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration ≤1 EU/μg
Gene Alias colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Common Name GM-CSF
Gene Symbol CSF2
Biological Activity ED50 = 10 ng/mL; determined by the dose-dependent proliferation of TF-1 cells.
Conjugate Unconjugated
Recombinant Recombinant
Sequence MAPTRPPSPV TRPWQHVDAI KEALSLLNNS NDTAAVMNET VDVVCEMFDP QEPTCVQTRL NLYKQGLRGS LTRLKSPLTL LAKHYEQHCP LTEETSCETQ SITFKSFKDS LNKFLFTIPF DCWGPVKK
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥95% using Coomassie staining
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