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  6. Thermo Scientific™ POROS™ Caprylate Mixed-Mode Cation Exchange Chromatography Resin

Thermo Scientific™ POROS™ Caprylate Mixed-Mode Cation Exchange Chromatography Resin

Catalog No. A51049
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Description

Thermo Scientific™ POROS™ Caprylate Mixed-Mode Chromatography Resin is designed to remove moderate to high levels of aggregates during downstream processing of therapeutic antibodies in flow-through mode.

POROS Caprylate Mixed-Mode Chromatography Resin is designed to remove moderate to high levels of aggregates during downstream processing of therapeutic antibodies in flow-through mode. As a mixed-mode, weak cation-exchange resin, POROS Caprylate resin effectively removes other impurities, such as host cell proteins and a wide range of high molecular weight species.

Features of POROS Caprylate Mixed-Mode resin include:

  • Selective capture of aggregates and hydrophobic high-molecular-weight impurities
  • Flow-through design that helps save buffer and material costs
  • Excellent scalability and high productivity
  • Wide operational range
  • Non-animal-derived

POROS Caprylate Mixed-Mode resin operates in flow-through mode which reduces costs, especially when working with more engineered monoclonal antibody derivatives. The unique selectivity of the caprylate ligand contributes to a high yield of the targeted monomer while using established cation exchange resin buffer systems.

Main characteristics

  • Matrix: cross-linked poly(styrene-divinylbenzene) POROS beads
  • Average particle size: 50 μm
  • Ligand: octanoic acid
  • Binding capacity: >20 g lysozyme/L resin
  • Typical buffers: typical cation exchange buffers, pH 4.5–7.0, conductivity 10–30 mS/cm
  • Clean-in-place: 0.5 M NaOH
  • Formulation buffer: 0.1 M NaOH
  • Mechanical resistance: 100 bar (10 MPa, 1450 psi)

POROS Caprylate Mixed-Mode resin is manufactured using a synthetic manufacturing process that is free of animal components.

Specifications

Matrix Poly(styrene-co-divinylbenzene)
Shipping Condition Ambient, cold
Particle Size 50 μm
Form Resin Slurry
Product Line POROS
Quantity 50 mL
Target Monoclonal antibodies
Type Bulk Resin
Stationary Phase Caprylic Acid
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