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Thermo Scientific™ POROS™ Caprylate Mixed-Mode Cation Exchange Chromatography Resin
Description
POROS Caprylate Mixed-Mode Chromatography Resin is designed to remove moderate to high levels of aggregates during downstream processing of therapeutic antibodies in flow-through mode. As a mixed-mode, weak cation-exchange resin, POROS Caprylate resin effectively removes other impurities, such as host cell proteins and a wide range of high molecular weight species.
Features of POROS Caprylate Mixed-Mode resin include:
- Selective capture of aggregates and hydrophobic high-molecular-weight impurities
- Flow-through design that helps save buffer and material costs
- Excellent scalability and high productivity
- Wide operational range
- Non-animal-derived
POROS Caprylate Mixed-Mode resin operates in flow-through mode which reduces costs, especially when working with more engineered monoclonal antibody derivatives. The unique selectivity of the caprylate ligand contributes to a high yield of the targeted monomer while using established cation exchange resin buffer systems.
Main characteristics
- Matrix: cross-linked poly(styrene-divinylbenzene) POROS beads
- Average particle size: 50 μm
- Ligand: octanoic acid
- Binding capacity: >20 g lysozyme/L resin
- Typical buffers: typical cation exchange buffers, pH 4.5–7.0, conductivity 10–30 mS/cm
- Clean-in-place: 0.5 M NaOH
- Formulation buffer: 0.1 M NaOH
- Mechanical resistance: 100 bar (10 MPa, 1450 psi)
POROS Caprylate Mixed-Mode resin is manufactured using a synthetic manufacturing process that is free of animal components.
Specifications
Specifications
| Matrix | Poly(styrene-co-divinylbenzene) |
| Shipping Condition | Ambient, cold |
| Particle Size | 50 μm |
| Form | Resin Slurry |
| Product Line | POROS™ |
| Quantity | 50 mL |
| Target | Monoclonal antibodies |
| Type | Bulk Resin |
| Stationary Phase | Caprylic Acid |
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