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  6. Thermo Scientific™ POROS™ Caprylate RoboColumn™ Pre-packed columns

Thermo Scientific™ POROS™ Caprylate RoboColumn™ Pre-packed columns
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Catalog No. A51057
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600 μL
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A51057 600 μL
A51056 200 μL
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Catalog No. A51057 Supplier Thermo Scientific™ Supplier No. A51057
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Description

These Thermo Scientific™ POROS™ Caprylate RoboColumn™ are pre-packed with POROS Caprylate Mixed-Mode Chromatography Resin to remove moderate to high levels of aggregates during downstream processing of therapeutic antibodies in flow-through mode.

These RoboColumns are pre-packed with POROS Caprylate Mixed-Mode Chromatography Resin to remove moderate to high levels of aggregates during downstream processing of therapeutic antibodies in flow-through mode. As a mixed-mode, weak cation-exchange resin, POROS Caprylate resin effectively removes other impurities, such as host cell proteins and a wide range of high molecular weight species. RoboColumns are small chromatography columns provided in 8-column strips. They are useful for fully automated and parallel chromatographic separations using robotic liquid handling platforms.

Features of POROS Caprylate Mixed-Mode resin include:

  • Selective capture of aggregates and hydrophobic high-molecular-weight impurities
  • Flow-through design that helps save buffer and material costs
  • Excellent scalability and high productivity
  • Wide operational range
  • Non-animal-derived

POROS Caprylate Mixed-Mode resin (Cat. No. A51051) operates in flow-through mode, which helps reduce costs, especially when working with more engineered monoclonal antibody derivatives. The unique selectivity of the caprylate ligand contributes to a high yield of the targeted monomer while using established cation exchange resin buffer systems. POROS Caprylate Mixed-Mode resin is manufactured using a synthetic manufacturing process that is free of animal components.

Main characteristics

  • Matrix: cross-linked poly(styrene-divinylbenzene) POROS beads
  • Average particle size: 50 μm
  • Ligand: octanoic acid
  • Binding capacity: >20 g lysozyme/L resin
  • Typical buffers: typical cation exchange buffers, pH 4.5–7.0, conductivity 10–30 mS/cm
  • Clean-in-place: 0.5 M NaOH
  • Formulation buffer: 0.1 M NaOH
  • Mechanical resistance: 100 bar (10 MPa, 1450 psi)

Other POROS chromatography resins are also available in this column format. All POROS high performance chromatography resins have a unique pore structure that provides excellent mass transport for high capacity and resolution over a wide range of flow rates.

RoboColumn™ is a registered trademark of ATOLL GmbH.

Specifications

Bed Volume 600 μL
Content And Storage

Store at 2–30°C.
Particle Size 50 μm
Product Line POROS
Quantity 600 μL
Target Monoclonal Antibodies
Type Pre-packed Column
Stationary Phase Caprylic Acid
Format Chromatography Column
Column Type High-throughput screening
Product Title
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