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Medchemexpress LLC Pozanicline dihydrochloride | 161416-61-1 | 99.1% | 265.18 | 10 MG
SDP

Catalog No. 5000344828
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Pozanicline dihydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. It is an α4β2-selective nAChR agonist, binding to rat brain α4β2 nAChR with a Ki of 17 nM, while its binding to α7 nAChR is insignificant.

  • Acts as a partial agonist at α4β2 nAChR.
  • Exhibits high selectivity for α6β2 and α4α5β2 nAChR subtypes.
  • Reverses nicotine withdrawal-induced deficits in contextual fear conditioning.
  • Investigated in phase 2 clinical trials for conditions such as attention deficit hyperactivity disorder, Alzheimer's disease, and nicotine addiction.

Catalog No. 50-003-44828 Supplier Medchemexpress LLC Supplier No. HY110160100MG
May include imposed supplier surcharges.
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Pozanicline dihydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. It is an α4β2-selective nAChR agonist, binding to rat brain α4β2 nAChR with a Ki of 17 nM, while its binding to α7 nAChR is insignificant.

  • Acts as a partial agonist at α4β2 nAChR.
  • Exhibits high selectivity for α6β2 and α4α5β2 nAChR subtypes.
  • Reverses nicotine withdrawal-induced deficits in contextual fear conditioning.
  • Investigated in phase 2 clinical trials for conditions such as attention deficit hyperactivity disorder, Alzheimer's disease, and nicotine addiction.

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