Apexbio Technology LLC PP 1 172889-26-8 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A82155.1

PP 1 (CAS 172889-26-8) is a selective inhibitor targeting the Src family of non-receptor protein tyrosine kinases including p56lck and p59fynT (IC50 5 nM and 6 nM respectively) Src kinases regulate signal transduction pathways influencing cell proliferation migration adhesion and survival making them important targets in cancer studies In vitro PP 1 selectively suppresses Lyn kinase in RBL-2H3 cells without affecting Syk kinase and effectively inhibits RET oncogene-driven transformation at nanomolar concentrations In vivo PP 1 reduces tyrosine phosphorylation events and T-cell proliferation highlighting its utility in research on Src kinase function and signaling pathways in oncology and immunology

Catalog No. 50-000-61979