Apexbio Technology LLC PP121 1092788-83-4 200mg

Supplier:  Apexbio Technology LLC B2172200

PP121 (CAS 1092788-83-4) is a dual inhibitor of tyrosine kinases and phosphoinositide kinases It demonstrates potent inhibition of PI3K isoforms p110 (IC50 52 nM) p110 (1 4 M) p110 (1 1 M) p110 (150 nM) as well as DNA-PK (60 nM) and mTOR (10 nM) it does not affect serine/threonine kinases PP121 also targets multiple tyrosine kinases including Ab1 (21 nM) Hck (4 nM) Src (10 nM) VEGFR2 (55 nM) EGFR (550 nM) EphB4 (220 nM) and PDGFR ( 1 nM) In cell-based studies PP121 reverses v-Src mediated cell transformation restores actin stress fiber staining and inhibits mutant Ret kinase in thyroid tumor models with sub-nanomolar potency It is used to investigate kinase cross-talk and mechanisms underlying drug resistance

Catalog No. 50-000-90104