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Medchemexpress LLC PPI-2458 | 431077-35-9 | 99.7% | 424.53 | 50 MG
SDP

Catalog No. 5000352247
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PPI-2458 is a potent, orally active, selective, and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). It is utilized in research for arthritis and lymphoma due to its significant inhibitory effects on cell proliferation and tumor growth.

  • Potently inhibits HUVEC proliferation with a GI50 of 0.2 nM and >95% maximum inhibition at 1 nM.
  • Inhibits proliferation and MetAP-2 in SU-DHL-16 cells in a dose-dependent manner.
  • Reverses joint swelling and inflammation in PG-PS-induced arthritis models.
  • Decreases germinal center lymphocytes in cynomolgus monkeys.
  • Significantly suppresses tumor growth in severe combined immunodeficient mice with SR tumor xenografts.

Catalog No. 50-003-52247 Supplier Medchemexpress LLC Supplier No. HY1373150MG
May include imposed supplier surcharges.
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PPI-2458 is a potent, orally active, selective, and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). It is utilized in research for arthritis and lymphoma due to its significant inhibitory effects on cell proliferation and tumor growth.

  • Potently inhibits HUVEC proliferation with a GI50 of 0.2 nM and >95% maximum inhibition at 1 nM.
  • Inhibits proliferation and MetAP-2 in SU-DHL-16 cells in a dose-dependent manner.
  • Reverses joint swelling and inflammation in PG-PS-induced arthritis models.
  • Decreases germinal center lymphocytes in cynomolgus monkeys.
  • Significantly suppresses tumor growth in severe combined immunodeficient mice with SR tumor xenografts.

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