Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000343162

Medchemexpress LLC Pptn hydrochloride | 1992047-65-0 | 99.89% | 511.96 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11032210MG

Encompass_Preferred

PPTN hydrochloride is a potent, high-affinity, competitive, and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. It shows no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. It also exhibits anti-inflammatory and anti-immune activity.

  • Potent, high-affinity, competitive, and highly selective P2Y14 receptor antagonist
  • Exhibits no agonist or antagonist effect at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors
  • Inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM (in the presence of 10 μM UDP-glucose) and ~4 nM (in the presence of 100 μM)
  • Significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38 at 10 μM
  • Anti-inflammatory activity
  • Anti-immune activity

Catalog No. 50-003-43162


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.