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Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 200 MG
Supplier: Medchemexpress LLC HY10996350MG
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. This compound demonstrates higher efficacy in specifically inhibiting cancer cells and shows low toxicity in normal cells.
- Potent PRMT5 inhibitor (IC50 = 7.5 μM)
- Exhibits anti-tumor activities
- Higher efficacy in inhibiting cancer cells with low toxicity in normal cells
- Inhibits colony-forming ability in PANC1 and HT29 cells
- Inhibits NF-κB activation and target gene expression in PDAC and CRC cells
- Decreases TNFα and IL8 expression in PDAC and CRC cells
- Displays significant anti-tumor effect in PANC1 and HT29 xenografted mice without visibly affecting body weight
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