Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML

Supplier:  Medchemexpress LLC HY109963100MG

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.

• Potent PRMT5 inhibitor.
• Exhibits anti-tumor activities.
• Low toxicity in normal cells.
• Strongly inhibits colony forming ability in PANC1 and HT29 cells.
• Inhibits NF-κB activation and its target gene expression.
• Decreases TNFα and IL8 expression.

Catalog No. 50-003-44132