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Apexbio Technology LLC Pracinostat (SB939) 929016-96-6 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A40955.1

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Pracinostat (SB939 CAS 929016-96-6) is an orally bioavailable inhibitor of histone deacetylases (HDAC) preferentially targeting class I II and IV HDACs with substantially lower affinity for class III enzymes By inhibiting these enzymes pracinostat promotes accumulation of acetylated histone H3 and acetylated -tubulin subsequently upregulating cell cycle regulator p21 In preclinical investigations SB939 demonstrated antiproliferative activity in various tumor cell lines including colon ovarian prostate cancers acute myeloid leukemia (AML) and B-cell lymphoma highlighting its potential utility in oncology research

Catalog No. 50-000-63952


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