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Medchemexpress LLC Praliciguat | 1628730-49-3 | 99.35% | 534.36 | 100 MG
Supplier: Medchemexpress LLC HY10903950MG
Praliciguat is a potent and orally active soluble guanylate cyclase (sGC) activator. It increases cGMP via the nitric oxide (NO)-sGC pathway, inhibits the expression of proinflammatory cytokines and apoptosis, and promotes vasodilation. It is used for research on metabolic and cardiovascular diseases, such as hypertension, diabetes, and heart failure.
- Potent and orally active soluble guanylate cyclase (sGC) activator
- Increases cGMP via the nitric oxide (NO)-sGC pathway
- Inhibits the expression of proinflammatory cytokines
- Inhibits apoptosis
- Promotes vasodilation
- Stimulates soluble guanylate cyclase in HEK-293 cells with an EC50 of 197 nM
- Reduces arterial pressure (MAP) in normotensive and hypertensive rats
- Attenuates proteinuria in obese ZSF1 rats model of diabetic nephropathy
- Attenuates inflammation, fibrosis, and end-organ damage in the Dahl rats model of cardiorenal failure
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