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Medchemexpress LLC Pravastatin (sodium) | 81131-70-6 | 99.0% | 5 G
Supplier: Medchemexpress LLC HYB0165A5G
Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with an IC50 of 5.6 μM. It is a statin used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease.
- Inhibits HMG-CoA reductase.
- For research use only.
- IC50 for inhibiting cellular steroidogenesis in HepG2 hepatocytes is 1.37 μM.
- IC50 for antimalarial activity against Plasmodium berghei NK65 in HepG2 hepatocytes is > 200 μM (after 48 hours by RT-PCR).
- Inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 of 0.1 μM.
- Inhibits cholesterol synthesis from [14C]- Acetate in hepatocytes of rats with an IC50 of 100 nM.
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