Apexbio Technology LLC PRE-084 hydrochloride 75136-54-8 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B63645.1

PRE-084 hydrochloride (CAS 75136-54-8) is a selective agonist of the sigma-1 receptor ( 1R) demonstrating high affinity and specificity over sigma-2 receptors (Ki values 2 2 nM for 1R 13091 nM for 2R) and negligible activity at PCP and other receptor systems (IC50 100 000 nM) In neuronal cell models expressing mutant huntingtin PRE-084 enhances NF- B pathway activation improving antioxidant responses and cell survival In vivo it reverses cognitive impairment induced by CO or trimethyltin and reduces cough response in guinea pig models highlighting PRE-084 as a relevant tool for neurological and respiratory research

Catalog No. 50-000-63932