Cayman Chemical PRE-084hydrochlorIde 50mg

Supplier:  Cayman Chemical 900132950 MG

A proteasome assembly modulator selectively activates the chymotrypsin-like trypsin-like and caspase-like activities of the 20S proteasome (EC50s 4.2 3.2 and 4.7 UM respectively) over the same activities of the 26S proteasome (EC50s >70 UM for all) but also inhibits the chymotrypsin-like activity of the 20S proteasome (IC50 1.44 UM) in cell-free assays increases the 20S proteasome-dependent degradation of a-synuclein and tau at 10 UM enhances disassembly of the 26S proteasome with a concomitant increase in 20S proteasome levels in HEK293T cells decreases tumor volume in an RPMI-8226 multiple myeloma mouse xenograft model at 100 mg/kg p.o. decreases infarct volume as a percentage of the area at risk in a mouse model of cardiac ischemia-reperfusion injury induced by left anterior descending coronary artery occlusion at a 50 mg/kg

Catalog No. 50-289-3738