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Vector Biolabs Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) Adenovirus (Ad-SIRT3)
Supplier: Vector Biolabs 1499
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. The human sirtuins, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 is widely expressed and regulates p53 function through its deacetylation at lysine 382.
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