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Vector Biolabs APC Adenovirus (Ad-CBR)
Supplier: Vector Biolabs 1283
Adenomatous polyposis coli gene (APC) is a tumor suppressor gene located on chromosome 5q2. It is inactivated in most colorectal tumors. APC is a cytoplasmic protein that can bind to and promote the degradation of b-catenin. In most colorectal tumors, APC is inactivated. This increases the interaction between b-catenin and Tcf family of transcription factors, leading to increase transcription of genes such as c-Myc. This adenovirus contains APC mini-me fragment. Shih IM., et al., Cancer Res. 2000 Mar 15;60(6):1671-6.
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