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Vector Biolabs Tumor necrosis factor receptor superfamily, member 10b Adenovirus (Ad-TRAILR2)
Supplier: Vector Biolabs 1356
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
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