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Cayman Chemical Precelys MInIlys Grey Fro 1ea
SDP

Supplier:  Cayman Chemical 387321 EA

Encompass

An inhibitor of the PRMT5/MTA complex selectively binds to the PRMT5/MTA complex over the PRMT5/SAM complex (Kds 0.14 and 9.4 pM respectively) selectively decreases protein dimethylarginine methylation levels in MTAP-/- HCT116 cells (IC50 8 nM) over wild-type HCT116 cells (IC50 653 nM) as well as selectively reduces the viability of MTAP-/- HCT116 cells (IC50 12 nM) over wild-type HCT116 cells (IC50 890 nM) reduces tumor volume in an MTAP-/- Lu-99 lung cancer mouse xenograft model at 12.5 to 100 mg/kg per day

Catalog No. 50-291-7160


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