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Apexbio Technology LLC Pregnenolone Carbonitrile(Synonyms: PCN, Pregnenolone-16α-carbonitrile, Pregn-5-en-20-one-16α-carbonitrile), 50mg, CAS: 1434-54-4.
Supplier: Apexbio Technology LLC C388450
Pregnenolone Carbonitrile (CAS 1434-54-4) known as Pregnenolone-16 -carbonitrile (PCN) is a pregnane X receptor (PXR) agonist primarily utilized in biomedical research investigating xenobiotic metabolism pathways By activating rodent nuclear PXR PCN stimulates expression of cytochrome P450 enzymes notably of the CYP3A subfamily enhancing hepatic detoxification and clearance of diverse foreign substances Independently of PXR PCN exhibits antifibrotic activity in liver fibrosis models shown by inhibition of hepatic stellate cell trans-differentiation in vitro and decreased hepatic fibrosis in vivo PCN thus serves as a useful tool for studying both PXR-dependent gene regulatory mechanisms and PXR-independent anti-fibrogenic effects
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