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Apexbio Technology LLC Preladenant 377727-87-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A37355.1

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Preladenant is a potent and selective antagonist targeting the adenosine A2A receptor (Ki 1 1 nM) developed from structural modifications of SCH 58261 Structurally it is a methoxy derivative carrying enhanced affinity and selectivity towards human and rat A2A receptors over A1 A2B and A3 subtypes Mechanistically Preladenant competitively blocks A2A receptor-mediated adenylate cyclase activation In preclinical studies Preladenant reduces Parkinsonian symptoms in primate and rodent models alone or in combination with L-Dopa thus widely employed in experimental research for Parkinson s disease and associated movement disorders

Catalog No. 50-000-62836


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