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Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 1 ML
Supplier: Medchemexpress LLC HY18174A10MM/1ML
Prexasertib dihydrochloride is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and exhibits potent anti-tumor activity. It also inhibits CHK2 and RSK1.
- Selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor.
- Causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis.
- Shows potent anti-tumor activity.
- Inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM).
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