Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.7% | 438.31 | 50 MG

Supplier:  Medchemexpress LLC HY18174A50MG

Prexasertib dihydrochloride is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with potent anti-tumor activity. It causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis.

• Selective CHK1 inhibitor with Ki of 0.9 nM and IC50 of <1 nM
• Also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM)
• Causes double-stranded DNA breakage
• Induces replication catastrophe and apoptosis
• Demonstrates potent anti-tumor activity
• Inhibits MELK (IC50=38 nM), SIK (IC50=42 nM), BRSK2 (IC50=48 nM), and ARK5 (IC50=64 nM)
• Requires CDC25A and CDK2 to induce DNA damage
• Causes chromosomal fragmentation in HeLa cells
• Induces replication stress and depletes RPA2 available for DNA binding
• Shows tumor growth inhibition in xenografts

Catalog No. 50-003-86906