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Medchemexpress LLC Prexasertib dimesylate (LY2606368 dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 100 MG
Supplier: Medchemexpress LLC HY18174E100MG
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor.
- Inhibits CHK2 and RSK1.
- Causes double-stranded DNA breakage and replication catastrophe.
- Induces apoptosis.
- Shows potent anti-tumor activity.
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