Biotium Primary Antibody CD45RA 158-4D3 CF740 1/EA

Supplier:  Biotium BNC740028500

Recognizes a protein of 205 kDa-220 kDa identified as CD45RA (Workshop III) CD45RA is isoforms of the human leukocyte common antigen (CD45) Human CD45 contains three exons which encode peptide segments designated A B and C respectively The differential splicing of the exons generates at least five isoforms ABC AB BC B and O This antibody reacts with ABC and BC isoforms CD45RA is expressed on 40-50% of peripheral CD4 T-cells 50% of peripheral CD8 T-cells B-cells and leukemic B-cell lines T-cells expressing CD45RA are naive or virgin T-cells T-cells expressing CD45RO are memory T-cells CD45RA and CD45RO define complementary predominantly non-overlapping populations of resting peripheral T-cells This MAb is useful in study on the subpopulation of CD4 or CD8 T-cells It can especially be used to differentiate T-cell lymphomas (CD45RO positive) from B cell lymphomas (CD45RA positive) Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF

Catalog No. 50-005-00740