Biotium Primary Antibody CD50 101-1D2 CF740 1/EA

Supplier:  Biotium BNC740177100

Recognizes an N-glycosylated glycoprotein of 120 kDa with intra-chain disulfide bonds identified as CD50 or ICAM-3 (WS IV and V) Its epitope localizes in the D2 extracellular domain and is resistant to neuraminidase and proteases CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signalling role to increase adhesion It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C This MAb inhibits primary mixed lymphocyte culture (MLC) but not secondary MLC cytotoxicity or proliferation induced by mitogens It blocks binding of NK1-L16 stimulated T cells to L cells expressing CD50 This MAb is excellent for staining of formalin/paraffin tissues Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets

Catalog No. 50-004-99627