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Biotium Primary Antibody CD53 63-5A3 CF740 1/EA
Supplier: Biotium BNC740356100
Recognizes a protein of 33-55 kDa identified as CD53 (Workshop V Code CD53 1) CD53 is expressed on monocytes and macrophages granulocytes dendritic cells osteoblasts and osteoclasts NK cells and on T- and B-cells from every stage of differentiation but is absent from platelets erythrocytes and non-haemopoietic cells CD53 is a member of a family of tetraspan transmembrane proteins including CD9 CD37 CD63 CD81 and CD82 It associates with integrins MHC class II molecules and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells monocytes and granulocytes and activation of the monocyte oxidative burst Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer
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