Biotium Primary Antibody Cytochrome c 7H8.2C12 CF740 1/EA

Supplier:  Biotium BNC740183500

Recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms In mammalian cells this highly conserved protein is normally localized to the mitochondrial inter-membrane space More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis During apoptosis cytochrome c is trans-located from the mitochondrial membrane to the cytosol where it is required for activation of caspase-3 (CPP32) Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c thereby blocking the apoptotic process Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner leading to caspase-9 cleavage of caspase-3

Catalog No. 50-004-99883