Biotium Primary Antibody Major Vault Protein 1032 CF740 1/EA

Supplier:  Biotium BNC740225100

Recognizes a protein of 104 kDa-110 kDa characterized as major vault protein (MVP) Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells They have a complex morphology including several small molecules of RNA but a single protein species The MVP accounts for greater than 70% of their mass Their shape is reminiscent of the nucleopore central plug Treatment of cells with estradiol increases the amount of MVP in nuclear extract The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate Antibodies to estrogen progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP MVP is overexpressed in many neoplastic tissues and cell lines Expression of MVP predicts a poor response to chemotherapy Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and

Catalog No. 50-005-00041