Biotium Primary Antibody p21 WAF1 WA-1 CF740 1/EA

Supplier:  Biotium BNC740043500

This MAb recognizes a 21 kDa protein identified as the p21WAF1 tumor suppressor protein This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53 Its expression is induced by the wild type but not mutant p53 suppressor protein Normal cells generally display a rather intense nuclear p21 expression Loss of p21 expression has been reported in many carcinomas (gastric carcinoma non-small cell lung carcinoma thyroid carcinoma) In ELISA MAb WA-1 is useful either as a solid phase or for detection of p21 protein Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note

Catalog No. 50-004-99380