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Biotium Primary Antibody Plasma Cell Marker LIV3G11 or 7B18 CF740 1/EA
Supplier: Biotium BNC740047500
This antibody recognizes an intra-cytoplasmic antigen which shows a very high degree of specificity for plasma cells This antigen is present in normal as well as neoplastic plasma cells Plasma cells which are large lymphocytes derived from an antigen-specific B cell secrete antibodies and are responsible for humoral immunity Plasma cells differentiate from B cells upon stimulation by CD4 lymphocytes The B cell acts as an antigen-presenting cell (APC) consuming an offending pathogen which is taken up by the B cell by phagocytosis and broken down within proteosomes Plasma cells contain basophilic cytoplasm their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed paraffin-embedded tissue sections It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic
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