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Biotium Primary Antibody Topoisomerase I Mitochondrial TOP1MT/488 CF740 1/EA
Supplier: Biotium BNC740488100
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands Due to their roles in DNA replication recombination and transcription DNA topoisomerases have been identified as targets of numerous anticancer drugs Mitochondrial Topo I (DNA topoisomerase I mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA As a type IB topoisomerase mitochondrial Topo I requires a divalent metal either calcium or magnesium as well as an alkaline pH for optimal activity x000D x000D Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets because blue dyes have lower fluorescence and can give higher
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