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Biotium Primary Antibody Tyrosinase T311 CF740 1/EA
Supplier: Biotium BNC740012100
Recognizes a cluster of proteins between 70-80 kDa identified as tyrosinase Occasionally a minor band at 55 kDa is also detected This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1 TRP-1/gp75 Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway the hydroxylation of tyrosine to L-3 4-dihydroxy-phenylalanine (dopa) and the subsequent oxidation of dopa to dopaquinone Mutations of the tyrosinase gene occur in various forms of albinism Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants This MAb is a useful marker for melanocytes and melanomas Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and CF405M
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