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Medchemexpress LLC PRMT5-IN-1 hydrochloride | 99.5% | 455.29 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY126256A10MG

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PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. It can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions. It is for research use only and not sold to patients.

  • Potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor
  • IC50 of 11 nM for PRMT5/MEP50
  • Inhibits the PRMT5/MEP50 complex very rapidly with a Kinact of 0.068 min-1 and a good binding affinity (KI=55 nM)
  • Inhibits the expression of cellular sDMA with an IC50 value of 0.012 μM in Granta-519 cells
  • Inhibits cell proliferation in a dose-dependent manner with an IC50 value of 0.06 μM in Granta-519 cells

Catalog No. 50-004-36284


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