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Medchemexpress LLC Prmt5-in-1 hydrochloride | 99.51% | 455.29 | 1 ML
Supplier: Medchemexpress LLC HY126256A10MM/1ML
PRMT5 IN-1 hydrochloride, a hemiaminal, is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 11 nM for the PRMT5/MEP50 complex. This compound can be converted to aldehydes and reacts with C449 to form covalent adducts under physiological conditions. As a hydrochloride salt, it typically offers enhanced water solubility and stability.
- Potent and selective inhibitor of PRMT5.
- Exhibits an IC50 of 11 nM for the PRMT5/MEP50 complex.
- Inhibits cellular sDMA in Granta-519 cells with an IC50 of 0.012 μM.
- Demonstrates antiproliferative activity in Granta-519 cells with an IC50 of 0.06 μM.
- Hydrochloride form provides enhanced water solubility and stability.
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