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Apexbio Technology LLC Probenecid 57-66-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B20145.1
Probenecid is an inhibitor targeting organic anion transporters multidrug resistance-associated proteins (MRPs) and pannexin-1 channels showing an IC50 of 150 M for pannexin-1 inhibition MRPs a class of ATP-binding cassette (ABC) transporters mediate efflux of diverse molecules across cellular membranes contributing to drug resistance Probenecid counteracts MRP-mediated drug resistance in multidrug-resistant tumor cell lines enhancing cellular sensitivity to chemotherapeutic agents like daunorubicin and vincristine In animal research Probenecid protects neurons against ischemia/reperfusion-induced injury suppressing inflammation-associated enzyme activity and reducing glial cell activation
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