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Cayman Chemical ProcynIdIn B4 1mg
Supplier: Cayman Chemical 363981 MG
A dual inhibitor of FTase and GGTase I (IC50s 2 and 98 nM respectively) inhibits prenylation of FTase and GGTase I substrates HDJ2 and Rap1a in PSN-1 pancreatic tumor cells (EC50s 92 and 6760 nM respectively) inhibits prenylation of the oncogenic protein Ki-Ras in PSN-1 cells in a concentration-dependent manner reduces HDJ2 and Rap1a prenylation ex vivo in dog PBMCs when administered at a dose of 35-50 mg/kg per day has no effect on Ki-Ras prenylation in patient-derived PBMCs inhibits lectin-induced expression of the T cell activation markers CD71 and CD25 on human PMBCs (IC50s 6 48 and 84 1 M respectively) inhibits IL-2-induced proliferation of CTLL2 cells (IC50 0 81 M)
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