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AdipoGen Profilin pAb IG-706
Supplier: AdipoGen AG25T0117C010
Polyclonal Antibody. Recognizes human, mouse, rat, pig, bovine and marsupial profilin. Source Rabbit. Applications ICC, IHC, WB. Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. Profilin PFN1 is a ubiquitous small 12-15kDa phosphoinositide and poly-L-proline binding protein that plays a role in signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties. Whereas profilin I appears to be highly expressed in most tissues except for skeletal muscle, profilin II is predominantly expressed in brain and at lower levels also in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes. Profilin binding to PIP2 interferes with PIP2 hydrolysis by soluble phospholipase C-gamma, an inhibition that can be overcome by tyrosine phosphorylation of PLC-gamma.
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