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Medchemexpress LLC Proguanil hydrochloride | 637-32-1 | 99.2% | 5 MG
Supplier: Medchemexpress LLC HYB0806A5MG
Proguanil hydrochloride is an antimalarial proagent that is metabolized to its active form, Cycloguanil. It functions as a dihydrofolate reductase (DHFR) inhibitor. While Proguanil itself has weak antimalarial activity, its effectiveness is primarily attributed to Cycloguanil. The combination of Atovaquone and Proguanil shows synergistic activity in vitro, effective against gametocytes and pre-erythrocytic (hepatic) stages of malaria parasites. Additionally, Proguanil, its metabolite 4-chlorophenyl-1-biguanide (CPB), and Cycloguanil reversibly inhibit 5-HT3 receptor responses.
- Metabolized to active form, Cycloguanil
- Functions as a dihydrofolate reductase (DHFR) inhibitor
- Exhibits weak antimalarial activity in vitro, enhanced by Cycloguanil
- Synergistic with Atovaquone against malaria parasites
- Inhibits gametocytes and pre-erythrocytic stages
- Reversibly inhibits 5-HT3 receptor responses
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