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Medchemexpress LLC Propanenitrile, 3-amino- | 151-18-8 | 99.99% | 70.09 | 1 G
Supplier: Medchemexpress LLC 1GHYY1750
β-Aminopropionitrile (BAPN) is a potent, specific, irreversible, and orally active inhibitor of lysyl oxidase (LOX), targeting the active site of LOX or LOXL isoenzymes. It has demonstrated the ability to normalize GLUT4 and adiponectin expression, along with improving glucose uptake in in vitro models of insulin resistance.
- Specific, irreversible, and orally active lysyl oxidase (LOX) inhibitor
- Normalizes GLUT4 and adiponectin expression
- Improves glucose uptake in insulin resistance models
- Blocks hypoxia-induced EMT morphological and marker protein changes
- Inhibits invasion and migration of cervical carcinoma cells in vitro
- Reduces body weight gain and improves metabolic profile in diet-induced obesity models in vivo
- Induces thoracic aortic dissection in C57BL/6 mice in vivo
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