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Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 10 G
Supplier: Medchemexpress LLC HY13048110G
Propargyl-PEG4-acid is a PEG-based PROTAC linker. It can be used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and analogue PROTAC 3, which causes BTK degradation. Propargyl-PEG4-acid is also a click chemistry reagent, featuring an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in synthesis of BTK-IAP PROTACs
- PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells
- Click chemistry reagent with Alkyne group
- Can undergo CuAAc with Azide groups
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