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Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 25 G
Supplier: Medchemexpress LLC 25GHY130481
Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 has demonstrated BTK degradation with a DC50 of 200 nM in THP-1 cells. This compound also serves as a click chemistry reagent, featuring an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of BTK-IAP PROTACs
- Functions as a click chemistry reagent
- Possesses an Alkyne group for copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
- Demonstrates BTK degradation in THP-1 cells
- Intended for research use only
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