Enzo Life Sciences Propenyl-L-NIO. hydrochloride (25mg)

Supplier:  Enzo Life Sciences ALX270497M025

Potent, selective inhibitor of iNOS (NOS II). The Ki values for inhibition of iNOS (NOS II), nNOS (NOS I), and eNOS (NOS III) by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics. However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS (NOS II) over nNOS (NOS I) or eNOS (NOS III). This selectivity results from iNOS (NOS II) exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS (NOS I). Ki values for ENIPO binding to iNOS (NOS II) and nNOS (NOS I) are 0.56 and 6 µM, respectively. Alternative name: N5-(1-Imino-3-butenyl)-L-ornithine, ENIPO . HCl. Purity: ≥97% (TLC). Solubility: Soluble in PBS, pH 7.2 (10mg/ml), 100% ethanol (10mg/ml), DMSO (2mg/ml) or dimethyl formamide (2mg/ml). Long Term Storage: -20°C.

Catalog No. 50-200-8621