Sigma Aldrich Propylphosphonic anhydride solution

Catalog No.	Quantity
43-130-350ML	50 mL
43-130-325L	2.5 L
43-130-3100ML	100 mL
43-130-310ML	10 mL
43-130-3500ML	500 mL

Catalog No. 43-130-350ML Supplier Sigma Aldrich Supplier No. 43130350ML

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

• Propylphosphonic anhydride (t3p) is a reactive n-propyl phosphonic acid cyclic anhydride. it is a mild and low toxic coupling agent used in peptide synthesis. t3p also acts as a promoter and water scavenger in the Friedländer annulation reaction. it participates in the conversion of carboxylic acids and amides into nitriles, formation of weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and c-c coupling reactions. t3p delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.propylphosphonic anhydride may be used in the following studies:
• As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs
• Microwave-assissted fischer indolization of arylhydrazines
• As acid activating agent for the direct synthesis of acid azides from carboxylic acids
• One-pot synthesis of coumarins
• Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones
• One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids
• Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.t3p is a registered trademark of archimica gmbh

Specifications

• CAS: 68957-94-8
• Density: 1.069 g/mL (at 25°C)
• Boiling Point: 65°C
• Molecular Formula: C9H21O6P3
• Linear Formula: C9H21O6P3
• Refractive Index: n20/D 1.418
• MDL Number: MFCD00006583
• Quantity: 50 mL
• Synonym: 1-Propanephosphonic anhydride solution; 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution; PPACA; T3P®
• Molecular Weight (g/mol): 318.18
• Biological Activity: Central Nervous System