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Cayman Chemical PROSGlnDN F2a ethyl aMD 10mg
Supplier: Cayman Chemical 1601610 MG
PGF2α-NEt is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity.{8837} PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.{8941} Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo,{8941} bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 UG/g corneal tissue/hr.{9311} PGF2α-NEt would be expected to show the typical intraocular effects of PGF2α free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
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