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AdipoGen Prostaglandin E2
Supplier: AdipoGen AGCL10001M001
Chemical. CAS 363-24-6. Formula C20H32O5. MW 352.5. Synthetic originally isolated from sheep prostate. One of the most typical lipid mediators produced from arachidonic acid AA by cyclooxygenase COX as the rate-limiting enzyme and acts on four kinds of receptor subtypes EP1, EP2, EP3 and EP4 with high binding affinity Kd values range between ~1-10nM. Regulator of numerous physiological functions ranging from reproduction to neuronal, metabolic and immune functions. Implied in the regulation of body temperature and sleep-wake activity. Regulating factor for bone formation and bone healing. Potent vasodilator. Influences smooth muscle relaxation, fertility and gastric mucosal integrity first line of defense of the intestinal immune system. Acts as a pro-inflammatory mediator, but also exerts anti-inflammatory responses.
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