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Medchemexpress LLC PROTAC B-Raf degrader 1 | 2364367-27-9 | 99.8% | 763.77 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1117581MG

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PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity.

  • Can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system.
  • Affects the expression of Mcl-1, a downstream protein of B-Raf.
  • Induces apoptosis in MCF-7 cells, with an apoptosis rate of 76.70% (64.00% early apoptosis, 12.70% late apoptosis) after 24 h incubation at 20 μM.
  • Arrests cell cycle at the G2/M phase.

Catalog No. 50-004-38982


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